Observation of Therapeutic Effect of Tacrolimus Ointment and Mometasone Furoate Cream in the Treatment of Chronic Actinic Dermatitis
- VernacularTitle:他克莫司软膏与糠酸莫米松乳膏治疗慢性光化性皮炎疗效观察
- Author:
Juan CHEN
;
Danqi DENG
;
Limei YUAN
;
Hanfei HU
;
Zhaoxia HAN
- Publication Type:Journal Article
- Keywords:
Chronic actinic dermatitis;
Tacrolimus;
Cytokine
- From:
Journal of Kunming Medical University
2014;(1):59-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of 0.1% tacrolimus ointment and 0.1% mometasone furoate cream in the treatment of chronic actinic dermatitis (CAD). Methods Forty male patients with CAD were recruited and divided into two groups randomly.Twenty cases were treated with 0.1%tacrolimus ointment (Group A), and the other 20 cases were treated with 0.1% mometasone furoate cream (Group B) . The medications mentioned were applied topically to the lesions on the face twice a day and mizolastine tablet 10 mg per day given orally for 4 weeks. The therapeutic efficacy and side effects of medications were observed. The enzyme linked immunosorbent assay (ELISA) method was used to measure the serum levels of IFN-γ, IL-2 and IL12 in CAD patients before and after treatment with topical tacrolimus ointment and mometasone furoate cream. Results (1) Both groups had overall response rates of 100%, with no statistically significant difference ( > 0.05) . (2) Serum levels of IFN-γ,IL-2 and IL-12 were down-regulated after treatment in both treatment groups respectively ( < 0.01) . No statistically significant difference was found between the two treatment groups ( > 0.05) . Conclusion 0.1%tacrolimus ointment is effective in the treatment of CAD. Its therapeutic efficacy is equivalent to that of 0.1%mometasone furoate cream. It can be used as a possible steroid sparing equivalent.
