Distributional Difference of CD3+T Lymphocyte in Tissue of Bladder Cancer and Epithelium of Paracancer Area
- VernacularTitle:CD3+T淋巴细胞在膀胱癌肿瘤上皮与癌旁尿路上皮中的分布差异研究
- Author:
Hui ZHAN
;
Jiansong WANG
;
Chengchuang WU
;
Haifeng WANG
;
Mingxia DING
;
Changxing KE
- Publication Type:Journal Article
- Keywords:
Urothelium carcinoma;
Paracancer tissues;
CD3+T lymphocyte;
Distribution
- From:
Journal of Kunming Medical University
2014;(1):28-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to observe the distribution of CD3+T lymphocyte in the tissue of bladder cancer and epithelium of paracancer area, and analyze the significance. Methods Biopsy was performed in 28 patients with bladder cancer, and the distribution and number of CD3+T lymphocyte in tissue of bladder cancer and epithelium of paracancer area were observed and compared using immunohistochemistry. Results Many of CD3+T lymphocytes could be observed in the epithelium of paracancer tissues, but CD3+T lymphocytes in cancer nests was few. The average number of CD3+T lymphocytes in every 5 typical microscope visual fields of paracancer tissues and cancer nests was 15 ±4.5 and 4 ±2.2, respectively, and the difference was significant ( <0.05) . Conclusion Distribution of CD3+T lymphocytes in bladder cancer nests and paracancer tissues was different, which may be related to the immune escape and prognosis of bladder cancer. It is worthy of further research.
