3.0T MR Susceptibility-weighted Imaging for Substantia Nigra Pars Compacta in Primary Parkinson’s Disease
- VernacularTitle:3.0T MR磁敏感加权成像对早期帕金森病黑质致密带的研究
- Author:
Bo WANG
;
Hongfei AN
;
Jie ZHANG
;
Guoli BI
;
Kunhua WU
;
Lixiang REN
;
Ling SHEN
- Publication Type:Journal Article
- Keywords:
Parkinson’s disease;
Substantia nigra pars compacta;
Brain iron deposition
- From:
Journal of Kunming Medical University
2014;(2):27-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the application of measurement of T2*value,width of substantia nigra pars compacta (SNc) and the ratio of the width to the midbrain diameter in diagnosing Parkinson disease (PD) in early stage with susceptibility weighted imaging ( SWI) by 3T MR. Methods 59 patients with early stage idiopathic PD patients and 59 healthy controls,ranging in same ages and gender,had been scanned with routine sequences and SWI sequences by 3T MR. T2*value,width and the ratio of the width to the midbrain diameter of SNc were measured. The results of measurement were analyzed and compared. Results (1) The T2*values, width and the ratio of the width to the midbrain diameter was decreased in homolateral side SNc of symptoms of subjects with PD compared with the healthy controls ( <0.05) . (2) There was a significant reduction in the T2*values and the ratio of the width to the midbrain diameter in contralateral side SNc symptoms of subjects with PD compared with the healthy controls (P<0.05) . There was no differences in width of SNc ( >0.05) . Conclusion Measurement of T2*value, width and the ratio of the width to the midbrain diameter of SNc with SWI is reliable to diagnose PD.
