The Correlation between Angiotensinogen Gene M235T Polymorphism and Hypertension Combined with Depression
- VernacularTitle:血管紧张素原（AGT）基因M235T多态性与中老年高血压并抑郁症的相关性研究
- Author:
Yingrong DU
;
Nihong LU
;
Yunhong WEI
- Publication Type:Journal Article
- Keywords:
Polymorphism;
Angiotensinogen;
Hypertension;
Depression
- From:
Journal of Kunming Medical University
2014;(2):57-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between angiotensinogen gene M235T polymorphism and gerontism hypertension combined with depression. Methods The polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) technique were used to detect the M235T genetic polymorphism in 117 patients with hypertension and 91 patients with hypertension and depression, and 101 healthy subjects without clinical evidence of hypertension and depression.Result The frequency of TT genetype and T allele was higher in group with hypertension and the group with hypertension and depression than that in the control group ( <0.05) . Conclusion Angiotensinogen gene M235T polymorphism is significantly correlated with the gerontism hypertension combined with depression.
