Effects of Voluven on plasma SOD and MDA of rabbits with hemorrhagic shock in high latitude
10.3969/j.issn.1671-8348.2014.06.018
- VernacularTitle:万汶对高原失血性休克兔SOD及M DA 的影响
- Author:
Leshun ZHOU
;
Shan OU
;
Shurong BAI
;
Maorong RAN
;
Lu LIN
- Publication Type:Journal Article
- Keywords:
high latitude;
shock;
superoxide dismutase;
activity and malondialdehyde;
Voluven
- From:
Chongqing Medicine
2014;(6):687-688
- CountryChina
- Language:Chinese
-
Abstract:
Objective To dynamically observe the changes of the plasma superoxide dismutase(SOD) activity and malondialde-hyde(MDA) content of rabbits with hemorrhagic shock in high latitude .Methods 28 rabbits were randomly divided into 4 groups :0 .9% NaCl group ,7 .5% NaCl group ,Voluven(6% HES 130/0 .4) group and control group .The plasma SOD activity and MDA content were measured before shock .At 30 minutes of shock and 30 minutes later of volumetric resuscitation .Then the changes of MAP were observed .Results There were no static difference among 4 groups in the levels of SOD and MDA before shock ;at 30 minutes of shock ,the SOD activity was reduced signicantly and the MDA content was increased in each group (P<0 .01) .Afer fluid infusion there were no obvious change in the plasma levels of SOD and MDA compared with those of shock in 0 .9% NaCl group and in 7 .5% NaCl group(P>0 .05) ,whereas in Voluven group ,compared with those in 0 .9% NaCl and 7 .5% NaCl group the SOD activity was elevated signicantly and the MDA content was decreased (P<0 .01) .Conclusion Voluven can be used in scan-venging oxygen free redicals by recovering the plasma SOD activity in rabbits with hemorrhagic shock in high latitude .
