Clinical observation of the effect of omeprazole, levofloxacin and metronidazole in the treatment of Helicobacter pylori induced chronic gastritis

VernacularTitle:奥美拉唑、左氧氟沙星和甲硝唑联合治疗幽门螺杆菌所致慢性胃炎疗效观察
Author: Aixian WANG
Publication Type:Journal Article
Keywords: Omeprazole; Left-Ofloxacin; Metronidazole; Chronic gastritis
From: Chinese Journal of Primary Medicine and Pharmacy 2014;21(2):221-223
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical efficacy of omeprazole,levofloxacin and metronidazole in the treatment of chronic gastritis caused by Helicobacter pylori.Methods 100 patients with chronic gastritis were selected as the research subjects.In accordance with digital table method,100 patients were randomly divided into the observation group and control group.Each group had 50 patients.The observation group was given triple therapy with omeprazole,levofloxacin and metronidasole.The control group was only given omeprazole.Results The total effective rate of the observation group was 94％,which was significantly higher than 82％ of the control group (x2 =7.37,P ＜ 0.05).The negative rate of Hp in observation group was 90％,which was significantly higher than 72％ of the control group (x2 =8.12,P ＜ 0.05).Conclusion The clinical efficacy of triple therapy of omeprazole,levofloxacin and metronidazole was better than the single therapy of omeprazole,which has significant effect,less adverse reactions.