Expression and amplification of the human epidermal growth fac-tor receptor 2 in different stages of urothelial bladder carcinoma
10.3969/j.issn.1000-8179.20131091
- VernacularTitle:浸润性尿路膀胱上皮癌中人类表皮生长因子受体-2表达与扩增的研究
- Author:
Haiming QIN
;
Qing JIN
;
Lin CHENG
;
Fulin SONG
;
Tong CUI
- Publication Type:Journal Article
- Keywords:
invasive urothelial bladder carcinoma;
human epidermal growth factor receptor-2;
immunohistochemistry;
fluores-cence in situ hybridization
- From:
Chinese Journal of Clinical Oncology
2014;(2):102-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the expression and gene amplification status of human epidermal growth factor receptor-2 (HER2) in the different stages of invasive urothelial bladder carcinoma. Methods:Tumor tissues from 49 patients with different stages of invasive urothelial bladder carcinoma were tested by immunohistochemical staining for HER2 and HER2 gene fluorescence in situ hybridization. Results:The number of male patients was higher than that of females. The positive rate of HER2 protein expression was higher in the patients with the higher stage of invasive urothelial bladder carcinoma. However, no gene amplification was observed in all patients. Twelve patients had ployploid chromosome 17. More ployploids were observed in the patients with the higher stage of inva-sive urothelial bladder carcinoma. Conclusion:The increase in the protein expression of HER2 in the invasive urothelial bladder carci-noma patients was not caused by gene amplification. Other transcriptional and post-transcriptional mechanisms were probably involved in the regulation of the HER2 protein.
