Cancer stem cells and tumor vascular heterogeneity
10.3969/j.issn.1000-8179.20130098
- VernacularTitle:肿瘤干细胞与肿瘤血管异质性
- Author:
Zhiyong LIU
;
Baocun SUN
- Publication Type:Journal Article
- Keywords:
vascular heterogeneity;
cancer stem cells;
angiogenesis;
transdifferentiation;
vasculogenic mimicry
- From:
Chinese Journal of Clinical Oncology
2014;(2):134-137
- CountryChina
- Language:Chinese
-
Abstract:
Neovascularization is the fundamental process during tumorigenesis and tumor malignant progression. According the traditional neovascularization theory, tumor vasculatures are mainly developed through angiogenesis by sprouting from preexisting ves-sels and vasculogenesis via recruitment of endothelial progenitor cells from the bone marrow, and the endothelial-dependant vessels are the only way that provides tumor with blood. However, more and more studies indicate that tumor microcirculation network is heteroge-neous and cancer stem cells (CSCs) play an important role during tumor neovascularization. This review highlights the contribution of CSCs to tumor microcirculation modes and the potential anti-angiogenesis targets. Furthermore, this review presents insights for perti-nent studies in the future.