Clinical efficacy of liver lesion with the treatment of reduced glutathione and ademetionine
- VernacularTitle:还原型谷胱甘肽联合腺苷蛋氨酸治疗化疗药物性肝损害的临床疗效
- Author:
Zhaoyan SHI
;
Weimin WANG
;
Songhua DENG
- Publication Type:Journal Article
- Keywords:
reduced glutathione;
ademetionine;
chemotherapeutics-induced liver lesion;
malignant tumors
- From:
Acta Universitatis Medicinalis Anhui
2014;(1):122-124
- CountryChina
- Language:Chinese
-
Abstract:
Clinical efficacy of liver lesion with the treatment of reduced glutathione and ademetionine was analyzed retrospectively. 83 patients were randomly divided into two groups based on the application of preventive hepatopro-tective drug. Control group was treated with reduced glutathione intravenous drip infusion once a day ( n =40 ) , while treatment group with reduced glutathione and ademetionine(Transmetil) once a day(n=43). After 12 days, the clinical efficacy of treatment group was better than that of control group. Total response rate was 95. 35% for treatment group, much better than that of control group(80. 00%). There was significant difference between two groups ( P<0.05 ) . Reduced glutathione and ademetionine are more effective in the treatment of chemotherapeutics-induced liver lesion than only with reduced glutathione.
