Biological role of microRNAs in gastric cancer
10.3969/j.issn.1000-8179.2014.20131932
- VernacularTitle:microRNA在胃癌中的生物学作用
- Author:
Yunyun TANG
;
Hailin TANG
;
Qi SU
- Publication Type:Journal Article
- Keywords:
gastric cancer;
miRNA;
biomarker;
diagnosis;
prognosis
- From:
Chinese Journal of Clinical Oncology
2014;(2):131-133
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNA) are a class of small non-coding RNA molecules that are rich in content and are highly con-served. miRNA can regulate vital biological processes, including cell division, differentiation, and cell apoptosis. Their expression is dysregulated in many diseases. miRNA are essential in the initiation and development of various cancers. Recent miRNA studies have gradually moved from basic molecular studies of cancer onto areas of clinical application. The use of miRNA as biomarkers for cancer diagnosis and target molecules for cancer treatment is increasingly being identified. This review summarizes the potential applications of miRNA as biomarkers for diagnosis and prognosis of gastric cancer, drug response, and susceptibility prediction.
