Significances of epithelial-mesenchymal transition and TGF-β1 expression in oral carcinoma
- VernacularTitle:上皮间质转化及 TGF-β1在口腔癌中的表达及意义
- Author:
Xia WANG
;
Shuhua WU
;
Peiyuan WANG
;
Yuhong ZHU
- Publication Type:Journal Article
- Keywords:
Epithelial-mesenchymal transition;
TGF-β1;
Metastasis;
Oral carcinoma
- From:
Journal of Practical Stomatology
2014;(2):277-279
- CountryChina
- Language:Chinese
-
Abstract:
Immunohisto-chemical S-P method was used to examine the expression of E-cadherin,Vimentin and TGF-β1 in 54 cases oral carcinoma and 10 cases of normal oral mucosa.The positive rates of the expression of E-cadherin,Vimentin and TGF-β1 were 55.6%, 33.33% and 59.3%,respectively in oral carcinoma group(vs normal oral mucosa,P <0.05).The expression of TGF-β1 was correlated with lymph node metastasis,and showed significant positive correlation with Vimentin.Epithelial-mesenchymal transition may promote inva-sion and metastasis of oral carcinoma,and TGF-β1 promotes EMT.
