Effect of trimetazidine combined with atorvastatin in the treatment of patients with coronary heart disease and its influence on lipid and hemorheology
10.3760/cma.j.issn.1008-6706.2014.02.016
- VernacularTitle:曲美他嗪联合阿托伐他汀治疗冠心病的疗效及对患者血脂和血液流变学的影响
- Author:
Yifang MAO
- Publication Type:Journal Article
- Keywords:
Trimetazidine;
Atorvastatin;
Coronary heart disease;
Lipids;
Rheology
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(2):195-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of trimetazidine combined with atorvastatin in the treatment of patients with coronary heart disease and its influence on serum lipid and hemorheology.Methods 140 cases with coronary heart disease were randomly divided into two groups.The control group was given trimetazidine on the basis of the conventional treatment,while the observation group was given atorvastatin on the basis of the control group.The clinical efficacy,changes of hemorheology and blood lipid were compared between the two groups.Results The effective rate of the observation group was 95.71％,which was significantly higher than 77.14％ of the control group (x2 =10.620,P ＜ 0.05).After treatment,TC,TG,LDL-C and HDL-C of the observation group were (2.54 ± 0.32) mmol/L,(1.41 ± 0.32) mmol/L,(1.53 ± 0.33) mmol/L and (0.73 ± 0.35) mmol/L,which were significantly lower than those of the control group (t =7.42,8.09,8.11,9.03,all P ＜ 0.05).After treatment,the nbh,nbl,np and HCT of the observation group were (5.11 ± 0.51) mPa/s,(8.03 ± 1.12) mPa/s,(1.02 ± 0.21) mPa/s and (40.34 ± 3.28) ％,which were significantly lower than those of the control group(t =8.33,9.14,8.08,9.44,all P ＜ 0.05).Conclusion Trimetazidine combined with atorvastatin in the treatment of coronary heart disease can significantly improve patients' lipid and hemorheology,and it can be promoted and applied in clinical practice.
