Clinical observation of three-dimensional conformal radiotherapy combined with S-1 for elderly patients with esophageal cancer
10.3760/cma.j.issn.1008-6706.2014.02.009
- VernacularTitle:替吉奥联合三维适形放疗治疗老年人食管癌临床观察
- Author:
Liqiang SONG
;
Juanjuan GAI
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
S-1;
Esophageal neoplasms;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(2):179-181
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of S-1 combined with synchronous three-dimensional conformal radiotherapy in the treatment of elderly patients with esophageal cancer.Methods 80 elderly patients with esophageal cancer were randomly divided into control group and the combination group,40 cases in each group.Three-dimensional conformal radiotherapy was applied in the two groups with a total dose of DT 60-64 Gy/ 30-32f.Patients in the combination group received S-1 chemotherapy concurrent with the radiotherapy on the first day.S-1 was orally given 80mg/m2 daily after meals from d1 to d14,21 days as a cycle and treated for 2 cycles.Results The total effective rate (CR + PR) of the combination group was 87.5％,that was 62.5％ of the control group,and there was statistically significant difference between the two groups (x2 =6.667,P =0.01).The one year overall survival rate of the two groups was 77.5 ％ and 57.5 ％,respectively,the difference was not significant (P =0.056).The incidence rate of hematological toxicity was higher in the combination group than that in the control group,but the toxic reaction was mild and tolerable.Conclusion The short-term curative effect of S-1 combined with three-dimensional conformal radiotherapy is feasible for elderly patients with esophageal cancer,and the toxicity is tolerable.
