The progress of mechanisms of mesenchymal stem cells in acute lung injury

VernacularTitle:间充质干细胞对急性肺损伤作用机制的研究进展
Author: Lu ZHU ; Xin SUN ; Liya HE ; Yan LU
Publication Type:Journal Article
Keywords: Mesenchymal stem cells; Acute lung injury; Mechanism
From: Chinese Pediatric Emergency Medicine 2014;21(2):112-115
CountryChina
Language:Chinese
Abstract: As a kind of source wide,low inherent immnunogenicity multipotent stromal cells,mesenchymal stem cells (MSCs) have been used to cell-based therapeutic researches of immunodeficient deseases or other severe clinical disorders.Despite low levels of engraftment in the injured lung,numerous preclinical trials indicate that mesenchymal stem cells can promote damaged tissue repair constructed by secreting paracrine factors to regulate the host immunity,inhibit inflammation and restore epithelial integrity.Acute lung injury(ALI) is a serious organ dysfunction occurred earliest and the most commonly affected organ.Currently there is no effective medicine therapy and the mortality remains high.Researches demonstrate MSCs can reduce alveolar edema,improve lung function and reduce motality.So understanding of the mechanism will be conductive to the MSCs from experimental stage into clinical application.This issue will put a brief overview pointed on the mechanism of mesenchymal stem cells in repairing the injured lung.