The role of Toll-like receptor 4 and peroxisome proliferator-activated receptorγ on pumonary vascular remodeling of chronic obstructive pulmonary disease
10.3760/cma.j.issn.1008-6315.2014.03.019
- VernacularTitle:TOLL样受体4、过氧化物酶体增殖物激活受体γ在慢性阻塞性肺疾病肺血管重塑的作用
- Author:
Lei DONG
;
Xinwen ZHANG
;
Jinpeng CONG
;
Wencheng YU
- Publication Type:Journal Article
- Keywords:
Chronic obstructive Pulmonary vascular remodeling;
Peroxisome proliferator-activated receptorγ;
Toll-like receptor 4
- From:
Clinical Medicine of China
2014;30(3):280-283
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role and correlation of peroxisome proliferator-activated receptor γ (PPAR-γ) and Toll-like receptor 4 (TLR4) on pulmonary vascular remodeling of chronic obstructive pulmonary disease(COPD).Methods Ninety male patients who underwent surgery for squamous cell carcinoma were enrolled as our subjects.All patients were divided into COPD group and uon-COPD group based on lung function,and 45 cases in each group.Peripheral lung tissues without tumor infiltrated after lobectomy were taken to assess the degree of arterial inflammation,percentage of wall thickness to vessel diamater (WT％) and percentage of wall area to total vascular area(WA％) were measured through Hematoxylin-Eosin(HE) staining under light microscope.The expression of PPARγand TLR4 were determined by immunohistochemistry.Results The distribution of WA％ and WT％ in COPD group were (43.98 ±6.43)％ and (27.37 ±3.34)％,higher than that of non-COPD group ((26.09 ± 2.82) ％,t =-13.949,P =0.000 ; (15.57 ± 1.75) ％,t =-7.140,P =0.000).The expression of PPAR-γand TLR4 in COPD group were (10.74 ± 8.81) ％,(3 1.41 ± 14.67) ％ respectively,and (28.22 ± 15.08)％,(4.67 ± 4.47)％ in non-COPD group.The differences were statistic significantly(t =5.483,P =0.000; t =-9.555,P =0.000).And there was negative correlation between the expression of PPARγand TLR4 (r =-0.404,P ＜ 0.01).Conclusion The pulmonary vascular of COPD patients showed the obviously inflammatory cell infiltration,fibrosis and proliferation,and PPAR-γ and TLR4 participate in the regulation of pulmonary vascular remodeling.
