Effects of Dezocine extended analgesia on serum interleukin-6 and substance P in laparoscopic surgery in patients
10.3760/cma.j.issn.1008-6706.2014.01.026
- VernacularTitle:地佐辛超前镇痛对腹腔镜手术患者血清白细胞介素-6和P物质的影响
- Author:
Baojun ZHANG
- Publication Type:Journal Article
- Keywords:
Dezocine;
Analgesis;
IL-6;
Substance P;
Laparoscopy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(1):58-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore dezocine preemptive analgesia in laparoscopic operation on serum interleukin-6(IL-6) and substance P.Methods 82 cases of laparoscopic operation were randomly divided into two groups,41 cases in the observation group,41 cases in the control group.Observation group was treated with routine anesthesia and analgesia with dezocine,the control group with routine anesthesia.Using visual analogue score (VAS) of pain scores,measured in the two groups of serum IL-6 and P material.Results The observation group after 2h,12h,24h VAS scores were (1.02 ±0.42),(2.19 ±0.87),(1.69 ±0.96) points,which were less than the control group (1.39 ±0.77)%,(3.08 ± 1.15)%,(2.27 ± 1.21)points (t =5.536 2,2.064 4,3.756 4,all P ＜0.05).The observation group before and after operation,serum IL-6,P material were (117.4 ± 17.2) mg/L,(204.4 ± 23.6) mg/L,(4.21 ± 0.96) mg/L,(4.33 ± 1.03) mg/L,the control group were (115.3 ± 14.7) mg/L,(276.5 ± 29.1) mg/L,(4.19 ± 0.94) mg/L,(6.92 ± 1.37) mg/L,two groups of postoperative serum IL-6,substance P (t =3.754 4,7.643 0,all P ＜ 0.05).Increased significantly,compared with the control group,the patients in the observation group the extent of small elevated(t =3.7544,7.6430,all P ＜ 0.05).Conclusion Dezocine extended analgesia in patients undergoing laparoscopic surgery can significantly reduce serum IL-6 and substance P expression.
