Changes of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in plasma before and after medical treatment of chronic obstructive pulmonary disease patients
10.3760/cma.j.issn.1008-6706.2014.01.024
- VernacularTitle:慢性阻塞性肺疾病患者治疗前后血浆基质金属蛋白酶-9及其抑制物-1水平的变化
- Author:
Wenjian WANG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Matrix metalloproteinase-9;
Tissue inhibitor of metalloproteinase-1
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(1):54-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in plasma before and after medical treatment of chronic obstructive pulmonary disease (COPD) patients.Methods 50 COPD patients in stage of attack were selected as case group,and were given routine medical treatment for 1 week,such as oxygen uptake,anti-infection,relieving cough and reducing sputum,spasmolysis and relieving asthma,and etc.The changes of MMP-9,TIMP-1 and MMP-9/TIMP-1 ratio levels before and after medical treatment were observed,and the clinical curative effect observation was carried on as well.Additionally,30 cases of normal personnels who were taking the physical examination at the same time were selected as the control group.Results The MMP-9,TIMP-1 and MMP-9/TIMP-1 ratio levels of patients in case group before medical treatment were much higher than those in control group (t =2.97,2.44,2.31,all P ＜ 0.05).After 1 week's medical treatment,the MMP-9,TIMP-1 and MMP-9/TIMP-1 ratio levels of patients in case group declined obviously than before(t =2.86,2.39,2.27,all P ＜ 0.05),and the total clinical efficiency reached 92.0% (46/50).Conclusion The MMP-9,TIMP-1 and MMP-9/TIMP-1 ratio levels in plasma of COPD patients are abnormally high,which can be the observation index of the severity of the disease and curative effect of COPD patients.
