Effects of IFN combined with adefovir dipivoxil in the treatment of patients with hepatitis B and hepatitis C overlapping infection

VernacularTitle:干扰素联合阿德福韦酯治疗乙型肝炎和丙型肝炎重叠感染疗效观察
Author: Liantao ZHANG ; Xiandong LIANG ; Wenliang ZHOU ; Zhiqiang REN
Publication Type:Journal Article
Keywords: Interferon alfa-2b; Adefovir dipivoxil; Hepatitis B; Hepatitis C
From: Chinese Journal of Primary Medicine and Pharmacy 2014;21(1):49-51
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical effect of IFN combined with adefovir dipivoxil in the treatment of patients with the hepatitis B and hepatitis C overlapping infection.Methods 90 cases of hepatitis B overlapping infection of hepatitis C were divided into control group(n =43) and treatment group(n =47).The control group was treated with IFN,the treatment group was treated with IFN and adefovir dipivoxil.Results The treatment group was better than the control group in the liver function,HBV DNA,HCV RNA.At the 24th weeks,the negative rates of HBV DNA and HCV RNA in the control group were 14 (32.6%) and 18 (41.9%),while there were were 38 (80.9%) and 34(72.3%) in the treatment group.There was significant differences between the two groups(x2 =6.43,5.28,all P ＜ 0.05).Conclusion The clinical efficacy of IFN combined with adefovir dipivoxil for the hepatitis B and hepatitis C overlapping infection patients was significant better than IFN,which is worthy of clinical application.