The role of human serum albumin therapy in the post-operative management of patients with hepatocellular carcinoma associated with cirrhosis
10.3760/cma.j.issn.1007-8118.2014.01.004
- VernacularTitle:肝癌合并肝硬化患者术后人血白蛋白应用方案的临床研究
- Author:
Rong HE
;
Li JIANG
;
Ke ZHANG
;
Yan LU
;
Baoliang LI
;
Zhe JIA
;
Yi MU
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Liver function;
Albumin;
Liver neoplasm;
Cirrhosis
- From:
Chinese Journal of Hepatobiliary Surgery
2014;20(1):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the role of human serum albumin therapy in the post-operative management of patients with hepatocellular carcinoma (HCC) associated with cirrhosis.Methods Between January 2011 and December 2012,we treated 171 consecutive cirrhotic patients with HCC.88 patients were treated with 5％ human serum albumin for 48 hours followed by 20％ human serum albumin in the post-operative period (the observer group) ; 81 patients were only treated with 20％ human serum albumin during the same time duration (the control group).The prognosis,complications,average amount of human serum albumin and plasma used as well as the in-hospital stay were observed.Results There were no deaths or major complications in either of these 2 groups.After treatment,the observer group was lower than the control group in the amount of intravenous fluid infused,the volume of peritoneal drainage,the amount of human serum albumin and plasma used as well as the mean post-operative hospitalization days (P ＜ 0.05).At the same time,the daily urine output,the central venous pressure and the mean arterial pressure within 48 hours after surgery were higher in the observer group than the control group.Furthermore the observer group had a smoother post-operative recovery in liver function,and the difference was significant between the two groups (P ＜ 0.05).Conclusion Not only did treatment with 5 ％ and 20％ human serum albumin gave the advantages of a more stable blood circulation,better organ perfusion and improved liver function recovery but it also reduced the amount of consumption of human serum albumin and plasma and shortened the hospital stay.
