The comparison of establishment of the acute myocardial infarction model between the beagle dogs and the mini-pigs by interventional technique
10.3969/j.issn.1671-8348.2014.09.024
- VernacularTitle:介入法建立比格犬和小型猪急性心肌梗死模型的对比研究
- Author:
Xiaolong GU
;
Jun HUANG
;
Zhenghua DONG
;
Huiyan LEI
;
Zhihua GONG
;
Yanfei WEN
;
Dingcheng XIANG
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
swine,minjature;
models,animal
- From:
Chongqing Medicine
2014;(9):1090-1092
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the success rate and the risk of establishment of the acute myocardial infarction model between the beagle dogs and the mini-pigs by interventional technique ,further to provid theoretical basis for choose a more suitable animal model .Methods 6 dogs and 6 mini-pigs were anaesthetized ,then underwent the coronary arteriography via femoral artery .After is-chemic preconditioning the coronary balloon was inflated to occlude the middle left anterior descending coronary for 180 minutes . The electrocardiogram was examined throughout the operation and the pathological sections were examined until the animals were executed one week later .Results All beagle dogs survived ,while 1 case of mini-pigs dead(1/6) .There was 1 cases(1/6) of beagle dogs had acute myocardial infarction ,while 5(5/6)cases in mini-pigs .All mini-pigs had malignant arrhythmia(6/6) but never seen in beagle dogs .The time needed for building a model was similar between the two groups ,the difference had no statistical signifi-cance(P>0 .05) .Conclusion The risk of establish myocardial infarction model in mini-pigs is higher than beagle dogs ,but the suc-cess rate is still high ,it might be the better choice .
