The randomized controlled trial of sequential therapy and standard therapy for eradicating the helicobacter pylori
10.3969/j.issn.1671-8348.2014.08.001
- VernacularTitle:序贯治疗与标准治疗根除幽门螺杆菌的随机对照研究
- Author:
Yongfu LU
- Publication Type:Journal Article
- Keywords:
helicobacter pylori;
gastritis;
sequential therapy
- From:
Chongqing Medicine
2014;(8):897-899
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the treatment countermeasures for the helicobacter pylori (Hp) related gastritis .Methods 103 cases atrophic gastritis and 120 cases of non atrophic gastritis were diagnosed by gastroscope and pathology ,and were randomly di-vided into three groups according to different treatment programs ,respectively .The 7 days standard treatment group(n=80) was taken orally proton pump inhibitors (nexium) 40 mg ,once everyday ,amoxicillin 1 .0 g ,once each 12 hours ,clarithromycin 0 .5 g , once each 12 hours(7 days);10 days sequential treatment group(n=73)was taken orally nexium 40 mg ,once ,amoxicillin 1 .0 g , once each 12 hours ,clarithromycin 0 .5 g ,once each 12 hours(7 days) ,then replaced with levofloxacin 0 .2 ,once each 8 hours ,fura-zolidone 30 mg ,once each 8 hours(3 days);12 days sequential treatment group(n=70) was taken orally nexium 40 mg ,once every-day ,amoxicillin 1 .0 g ,once each 12 hours ,clarithromycin 0 .5 g ,once each 12 hours(7 days) ,then replaced with levofloxacin 0 .2 g , once each 8 hours ,furazolidone 30 mg ,once each 8 hours(5 days) .Results After treatment ,the performance under endoscopy and pathology of three groups had no significant differences(P>0 .05) .The eradication rate of standard treatment group was 76 .6%(59/77) ,10 days sequential treatment group was 88 .4% (61/69);12 days sequential treatment group was 97 .0% (64/66) .The cur-ative effect had statistically significant between 7 days standard treatment group and 12 days sequential treatment group(P<0 .05) . Conclusion Sequential treatment was obviously superior to the standard treatment for eradicating Hp .
