The plasma levels change of TNF-α,IL-6,IL-10,PLA2 and organ lesion analysis of sever burn injury patients with sepsis
10.3969/j.issn.1671-8348.2014.08.015
- VernacularTitle:严重烧伤脓毒症患者血清 TNF-α、IL-6、IL-10、PLA2的变化及器官功能损害状况分析
- Author:
Kai CHEN
- Publication Type:Journal Article
- Keywords:
burn;
multiple organ failure;
tumor necrosis factor-alpha;
interleukins;
phospholipase A2
- From:
Chongqing Medicine
2014;(8):937-940
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study plasma levels of tumor necrosis factor-α(TNF-α) ,IL-6 ,IL-10 ,serum phospholipase A2(PLA2) and organ lesion of sever burn injury patients .Methods 57 sever burn injury patients got treated in our department from March 2010 to March 2011 ,in which 33 of them had been diagnosed with sepsis and 19 of which developed into multiple organ dysfunction syndrome(MODS) ,the levels of IL-6 ,IL-10 ,TNF-α,PLA2 were compared among sepsis group(group N) ,MODS group(group M) and negative group(group N) .The organ disfunction and fatality rate were also analyzed .Results The PLA2 ,TNF-α,IL-6 levels of patients in group S and M were significantly higher than group N ,and showed no apparent decline during the first 14 day ;the change trend of IL-10 had no statistically significant difference among the 3 groups(P<0 .05) .The group S and M showed larger burned area and deeper burned depth ,the organ failure and mortality rate were significantly higher than group N ,And with the most common respiratory function failure .Conclusion The PLA2 ,TNF-α,IL-6 levels in sever burn injury patients might be closely relat-ed to the degree of burn .High plasma level of PLA2 ,TNF-α and IL-6 might be closely associated with occurrence of sepsis and MODS and their outcome .
