The expression and clinical significance of PTEN,P27 and BAG-1 in endometrial carcinoma
10.3969/j.issn.1671-8348.2014.07.006
- VernacularTitle:PTEN、P27和BAG-1在子宫内膜癌中的表达及临床意义
- Author:
Yanfang LIANG
;
Jincheng ZENG
;
Dongping KANG
;
Lingmei WANG
;
Can CHEN
;
Jianbo RUAN
- Publication Type:Journal Article
- Keywords:
immunohistochemistry;
endometrial neoplasms;
PTEN;
P27;
BAG-1
- From:
Chongqing Medicine
2014;(7):785-787
- CountryChina
- Language:Chinese
-
Abstract:
Objective To stduy the expression of PTEN ,P27 and BAG-1 in endometrial carcinoma ,and to analysis the clinical significance .Methods The expression of PTEN ,P27 and BAG-1 in 102 cases of endometrial carcinoma ,90 cases of endometrial hy-perplasia and 44 cases of normal endometrium tissue were detected by immunohistochemistry .Results PTEN and P27 in endome-trial carcinoma and hyperplasia tissue showed lower expression ,BAG-1 showed high expression in them .The expression of PTEN and BAG-1 were well correlated to histology degree and muscular infiltration .BAG-1 expression also had a well correlated to clinical stage .In this study ,we had not find a correlated between the expression of P27 and clinical and pathology characteristic of patien . PTEN expression had a Pearson relevance to P27 or BAG-1 expression ,but there was no correlation between P27 and BAG-1 .Con-clusion PTEN and P27 in endometrial carcinoma and hyperplasia tissue showed lower expression ,BAG-1 showed high expression in them .PTEN ,P27 and BAG-1 might play a role in the development of endometrial cancer .
