Evaluate the security of the treatment of a new bioartificial liver system with experimental pig model
10.3969/j.issn.1671-8348.2014.09.005
- VernacularTitle:西藏猪模型对新型生物人工肝治疗安全性的评估
- Author:
Longhui XIONG
;
Guolin HE
;
Zhi ZHANG
;
Yan WANG
;
Mingxin PAN
;
Yi GAO
- Publication Type:Journal Article
- Keywords:
liver,artificial;
security;
vital signs;
pressure monitoring values;
bacteria endotoxin test;
swine;
models,animal
- From:
Chongqing Medicine
2014;(9):1038-1040
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the security of big animals with a new bioartificial liver system .Methods Six Tibet pigs re-spectively received treatment of hybrid artificial liver and simple bioartificial liver ,observed and recorded the vital signs ,venous pressure ,transmembrane pressure and slurry pot pressure each hour ,and collected blood to make endotoxin and bacterial culture test in the zero hour ,fourth and eighth hour .Results Compared with the zero hour ,venous pressure ,transmembrane pressure ,slur-ry pot pressure were much higher in the fifth hour (P< 0 .05) ,and there were no significant difference in the rest of other time points(P>0 .05) .The mean arterial pressure and respiratory rate in all time point showed no significant changes (P>0 .05) .Com-pared with the zero hour ,the heart rate was much lower in the second hour (P<0 .01) .The values of blood endotoxin were less than 0 .5 EU/mL in the zero hour ,fourth and eighth hour from beginning ,and the bacterial culture test showed no growth of bacteria . Conclusion The experiment of big animals with a new bioartificial liver system was safe ,the efficacy in the treatment of hepatic failure could be assessed further .
