Analysis of ERCC1 mRNA expression to predict prognosis in patients with non-small cell lung cancer who received adjuvant chemotherapy

VernacularTitle:非小细胞肺癌组织中ERCC1mRNA表达的及其与辅助化疗和预后的关系
Author: Hong ZHONG ; Xuefeng LENG ; Nuo YANG ; Mingwu CHEN ; Jianji GUO ; Lei XIAN
Publication Type:Journal Article
Keywords: carcinoma,non-small cell lung; ERCC1 mRNA; reverse transcriptase polymerase chain reaction
From: Chongqing Medicine 2014;(9):1058-1060
CountryChina
Language:Chinese
Abstract: Objective To discover the excision repair cross-complementing 1 (ERCC1) expression in non-small cell lung cancer (NSCLC) patients and explore the prognostic value of ERCC1 .Methods The ERCC1 mRNA expressions in NSCLC was tested from 85 tumor tissues and 34 adjacent tissue samples from patients who were after the surgery were used by semi-quantitative RT-PCR .The data of clinical features and progression-free survival (PFS) and overall survival (OS) were linked to ERCC1 expression by retrospective analysis .Results In 85 patients ,the ERCC1 negative ones had a significantly longer survival than the ERCC1 posi-tive expression ones (PFS ,P=0 .001;OS ,P=0 .001) .During the multivariate analysis ,ERCC1was found to be a significant factor in PFS and OS (P=0 .018 and P=0 .027) .Conclusion NSCLC patients who were undertaken platinum-based adjuvant chemother-apy after surgery could use the detection of ERCC1 mRNA as a determinant factor for the prognosis predicting of individualized treatment .