Preliminary study on peroxisome proliferator activated receptor gamma of lymphocytes in patients with asthma

VernacularTitle:过氧化物酶体增殖物激活受体γ在哮喘患者淋巴细胞中的表达
Author: Chunrong ZHANG ; Yan ZHAO ; Daoxin WANG
Publication Type:Journal Article
Keywords: asthma; lymphocytes; PPAR gamma
From: Chongqing Medicine 2014;(9):1063-1065
CountryChina
Language:Chinese
Abstract: Objective To explore the peroxisome proliferator activated receptor gamma (PPARγ) expression characteristic of lymphocytes in patients with asthma .Methods Collected blood samples from healthy subjects (health control group) and asthmatic patients(asthmatic group) before treatment ,2 and 4 days after treatment .Expression levels of PPARγtested with Q-PCR .Analyzed eosinophil percentage of induced sputum ,IL-5 concentration in sputum supernatant measured with ELISA kits .Results Compared with healthy control group ,the eosinophil percentage and IL-5 concentration were higher in asthmatic group before treatment ;meanwhile the expression level of PPARγwas at the lowest .After treatment ,PPARγgradually increased accompanied with eosino-phil percentage and IL-5 concentration gradually decreased .Conclusion Asthmatic patients had a lowest PPARγ expression level . Their recovery perhaps attributed to the up-regulation of PPARγin lymphocytes .The anti-inflammatory effect of PPARγachieved might be via inhibiting the function of Th2 cells .