The clinical observation of ketamine attenuates neutrophil activation after cardiopulmonary bypass

VernacularTitle:氯胺酮减轻心肺转流后中性粒细胞激活作用的临床观察
Author: Shuang WU ; Jie TAN ; Jingxiang WU
Publication Type:Journal Article
Keywords: ketamine; superoxides; neutrophils; cardiopulmonary bypass
From: Chongqing Medicine 2014;(9):1078-1080
CountryChina
Language:Chinese
Abstract: Objective To investigate the application of small dose of ketamine during induction of anesthesia in patients after coronary artery bypass grafting neutrophil superoxide generation effect .Methods 30 patients undergoing elective coronary artery bypass grafting operation were randomly divided into 2 groups ,in the fentanyl induced respectively based on combined with small dose of ketamine (ketamine group) or normal saline (control group) ,a blood sample collection time points :before ,immediately after extracorporeal circulation operation ,operation after 1-6 days .Neutrophil function by using (12-) fourteen acid and phorbol ester (-13-) acetate (PMA) ,yeast polysaccharide or formyl-methylthio-light-phenylalanine after stimulation of superoxide production de-termination method .Results During general anesthesia combined with low dose ketamine inhibits superoxide anion increases .In ad-dition ,ketamine reduces perioperative 2 -6 days of the neutrophil percentage .Conclusion Ketamine can reduce the activation of neutrophils after cardiopulmonary bypass .