Investigation of the change in redox state of plasma factor Ⅺ in elderly type 2 diabetic patients with macroangiopathy
10.3760/cma.j.issn.0254-9026.2014.01.007
- VernacularTitle:还原型凝血因子Ⅺ在老年2型糖尿病合并大血管病变患者血浆中的变化
- Author:
Lu GAO
;
Qiumei ZHANG
;
Jianying SHI
;
Demin YU
- Publication Type:Journal Article
- Keywords:
Factor Ⅺ;
Diabetes mellitus,type 2;
Diabetic angiopathies
- From:
Chinese Journal of Geriatrics
2014;33(1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential effect of the redox state of plasma factor Ⅺ (FXI) on the pathogenesis of elderly diabetic hypercoagulability and macroangiopathy.Methods The plasma levels of reduced FXI were detected in elderly type 2 diabetic(T2DM)patients with/without macroangiopathy (T2DM group/DMAP group) and healthy subjects (control group),and variables associated with reduced FXI were analyzed.Results Elderly patients with T2DM had higher plasma levels of reduced FXI as compared with healthy controls.The level of reduced FXI was significantly higher in patients with macroangiopathy than without macroangiopathy [control group:(80.6± 15.6) ％,T2DM group:(94.7 ± 16.0) ％,DMAP group (142.6 ± 36.5) ％,all P＜ 0.05].The multiple stepwise regression analysis showed that plasma levels of triglyceride,cholesterol and HDL-cholesterol were the independent predictors for reduced FXI.Conclusions The plasma level of reduced FXI is increased in elderly T2DM patients with macroangiopathy.The abnormality of lipid profiles may associate with the increment of reduced FXI.These findings maybe provide the novel mechanisms for diabetic hypercoagulability and macroangiopathy.
