Intervention effect of Bushen-Yixin tablet on the level of NOS, NO and Ang (1-7) in spontaneously hypertensive rat
10.3760/cma.j.issn.1673-4246.2014.02.009
- VernacularTitle:补肾益心片对高血压模型大鼠一氧化氮合酶、一氧化氮及血管紧张素1-7的干预作用
- Author:
Song WANG
;
Rong LI
;
Zhaohui GONG
;
Yude LIU
;
Xuejie ZHENG
;
Wei WU
- Publication Type:Journal Article
- Keywords:
Bushenyixin tablet;
Valsartan;
Essential hypertension;
Ang1-7
- From:
International Journal of Traditional Chinese Medicine
2014;36(2):128-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the variation of the level of NOS,NO and Ang (1-7) in spontaneously hypertensive rat(SHR).Methods SHR were divided randomly into 3 groups:Bushenyixin group(n=8),valsartan group (n=8),and model group (n=7).Each group was given Bushenyixin tablet,valsartan,and saline by gavage respectively.After 4 weeks,the concentration of NOS,NO,Ang (1-7) in plasma and the concentration of NOS,NO in aorta were be observed.Results The concentration of NO in plasma was significantly lower in the Bushen-Yxin group than for model group(15.500±4.375)μmol/L vs.(26.000±2.828)gmol/L,P＜0.05.The concentration of NO in aorta and Ang1-7 in plasma were significantly higher in the Bushen-Yixin group than in the model group [(35.604±7.505)μmol/L vs.(17.437± 11.649) μ mol/L,(45.542 ± 12.726)ng/L vs.(25.521 ± 2.727) ng/L,P＜0.05].The concentration of NO in aorta was significantly higher in Bushen-Yixin group than in the valsartan group [(21.537± 13.484) μmol/L,P＜0.05].Conclusion Bushen-Yixin tablet had effects of increasing of NO level in aorta and Ang (1-7) level in plasma in spontaneously hypertensive rat.
