Anaphylaxis following atropine administration during general anesthesia: a case report.
10.4097/kjae.2015.68.5.496
- Author:
Jaekyu CHOI
1
;
Hyunchang KIM
;
Yun Seok JEON
;
Deok Man HONG
Author Information
1. Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea. mellyn7@gmail.com
- Publication Type:Case Report
- Keywords:
Anaphylaxis;
Atropine;
General anesthesia;
Intradermal tests
- MeSH:
Adult;
Anaphylaxis*;
Anesthesia, General*;
Angioedema;
Atropine*;
Erythema;
Humans;
Hypotension;
Immunoglobulin E;
Immunoglobulins;
Intradermal Tests;
Male;
Nausea;
Risk Factors;
Tryptases;
Urticaria;
Vomiting
- From:Korean Journal of Anesthesiology
2015;68(5):496-500
- CountryRepublic of Korea
- Language:English
-
Abstract:
Anaphylaxis is an acute, potentially lethal, multisystem syndrome resulting from the sudden release of mast-cell- and basophile-derived mediators into the circulation. Common manifestations of anaphylactic reactions include urticaria, angioedema, nausea, vomiting, hypotension and cardiovascular collapse. Cardiovascular collapse is the first detected manifestation in up to 50% of cases in perioperative anaphylaxis, because patients are anesthetized and unable to report symptoms. A 25-year-old male presented with severe hypotension and erythema after intravenous atropine administration during general anesthesia. Postoperative laboratory findings demonstrated elevated serum tryptase and total immunoglobulin E. An intradermal test showed atropine sensitivity. Although atropine is used widely as a perioperative anticholinergic agent, it is a potential risk factor for a severe anaphylactic reaction. Therefore, prompt recognition and adequate therapeutic measures are necessary to avoid fatal consequences.
