Significance of peripheral blood interleukin-12 in capillary bronchiolitis patients
10.3760/cma.j.issn.1673-4912.2014.01.005
- VernacularTitle:毛细支气管炎患儿外周血白细胞介素-12的意义
- Author:
Xiufang WANG
;
Huibin YANG
;
Li SONG
;
Yanli ZHANG
;
Chunna XU
- Publication Type:Journal Article
- Keywords:
Capillary bronchiolitis;
Interleukin-12;
Idiocrasy;
Infants
- From:
Chinese Pediatric Emergency Medicine
2014;21(1):13-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the role of interleukin (IL)-12 in capillary bronchiolitis disease.Methods Fifty-nine cases of capillary bronchiolitis children under 2 years old were enrolled as the bronchiolitis group Ⅰ(n =28) and bronchiolitis group Ⅱ(n =31),36 cases of children with bronchopneumonia of the same age and 31 cases of children suffered from non-infectious diseases such as hernia and renal calculus of the same age were enrolled as bronchopneumonia control group and normal control group respectively.The peripheral blood IL-12 levels of four groups were detected by enzyme-linked immunosorbent assay.Results The levels of the peripheral blood IL-12 in bronchiolitis group Ⅰ,bronchiolitis group Ⅱ,bronchopneumonia control group and normal control group were (34.72±7.96) pg/ml,(55.30 ±6.72) pg/ml,(56.79±10.36) pg/ml and (61.23 ± 11.51) pg/ml respectively.The level of the peripheral blood IL-12 in bronchiolitis group I was significantly lower than that in bronchiolitis group Ⅱ,bronchopneumonia control group and normal control group respectively (P ＜0.05),and the level of the peripheral blood IL-12 in bronchiolitis group ⅡⅡ was significantly lower than that in bronchopneumonia control group and normal control group respectively (P ＜ 0.05),but there was no significant difference between bronchopneumonia control group and normal control group (P ＞ 0.05).Conclusion The level of IL-12 is one of the important factors for bronchiolitis disease,the reducing of serum level of IL-12 in children who have a high risk factor of capillary bronchiolitis is more obvious.
