Efficacy of intravenously use of ambroxol in treatment of mechanical ventilation patients:A Meta-analysis

VernacularTitle:盐酸氨溴索静脉给药对有创机械通气患者疗效影响的Meta分析
Author: Caiyun DING ; Yue XU ; Jing ZHANG ; Jianhua ZHU ; Hong HE
Publication Type:Journal Article
Keywords: Ambroxol; Mechanical ventilation; Meta-analysis
From: Chinese Journal of Practical Nursing 2014;30(4):15-21
CountryChina
Language:Chinese
Abstract: Objective To evaluate the therapeutic effect of intravenously use of ambroxol in treatment of mechanical ventilator patients.Methods Meta-analysis was used.The Cochrane Library,PubMed,Elsevier (ScienceDirect),OVID series medical databases and domestic main databases were searched,the quality of included studies was evaluated by certain standards.The Review Manager 5.0 software was used for analysis.Results 14 studies were included,1 184 mechanical ventilation patients were involved.The Meta-analysis showed that there were significant differences between two groups in blood gas analysis,airway resistance and pressure and lung compliance.However,there were no differences between two groups in expectorant effect and VAP incidence.Conclusions Intravenously use of ambroxol in treatment of mechanical ventilator patients was effective.A large multi-center sample of high-quality clinical studies is needed to confirm the results.