Clinical value of platelet parameters for the assessment of liver function in chronic hepatitis B liver cirrhosis
10.3760/cma.j.issn.1673-4904.2014.03.011
- VernacularTitle:血小板参数对慢性乙型肝炎肝硬化及肝功能评估的临床价值研究
- Author:
Xiaoming XU
- Publication Type:Journal Article
- Keywords:
Blood platelets;
Liver cirrhosis;
Hepatitis B
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(3):33-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of platelet parameters for the assessment of liver function in chronic hepatitis B (CHB) liver cirrhosis.Methods A total of 167 patients with CHB liver cirrhosis (CHB liver cirrhosis group) were selected,according to Child-Pugh score of liver function classification:A grade 48 cases (A grade group),B grade 65 cases (B grade group),C grade 54 cases (C grade group).Fifty healthy cases were chosen as control group,then compared blood platelet count (PLT),platelet distribution width (PDW),mean platelet volume (MPV) levels differences between every group,and these indicators were analyzed.Results PLT,MPV,PDW was(88.53 ± 21.36) × 109/L,(9.47 ± 2.02) fl,(12.41 ± 1.16) fl in CHB liver cirrhosis group,and (172.64 ± 37.42) × 109/L,(11.47 ± 2.16) fl,(10.49 ±0.83) fl in control group,and PLT,MPV were significantly reduced (P ＜0.01),and PDW increased significantly in CHB liver cirrhosis group compared with control group (P＜ 0.01).PLT in A,B,C grade group [(123.78 ± 26.35) × 109/L,(84.96 ± 31.62) × 109/L,(61.48 ± 27.13) × 109/L] was lower than that in control group,and there was significant difference (P＜ 0.01).There was no significant difference in MPV,PDW between A grade group and control group (P ＞0.05).There was no significant difference in MPV,PDW between B grade,C grade group and control group [(9.68 ±2.23),(8.65 ±2.19) fl vs.(11.47 ±2.16) fl and (12.26 ± 1.35),(14.13 ± 1.54) fl vs.(10.49 ±0.83) fl](P＜0.05 or ＜0.01).Correlation analysis showed that PLT,MPV was positively correlated with liver function (r =0.365,0.473,P ＜0.05).But PDW was nagtively correlated with liver function (r =-0.512,P ＜0.05).Conclusions Platelet parameters such as PLT,MPV,PDW are good to evaluate the liver function and it's compensatory of CHB liver cirrhosis,and that dynamic changes of the parameters has important clinical significance in the disease assessment and treatment of liver cirrhosis.
