Biological properties of biphasic tricalcium phosphate bioceramics/calcium sulfate bone cement porous three-dimensional scaffolds
10.3969/j.issn.2095-4344.2014.08.003
- VernacularTitle:双相钙磷生物陶瓷/硫酸钙骨水泥多孔三维支架的生物性能
- Author:
Yingyun TAN
;
Shi BAI
;
Yunmao LIAO
- Publication Type:Journal Article
- Keywords:
biocompatible materials;
calcium sulfate;
hydroxyapatites;
osteoblasts
- From:
Chinese Journal of Tissue Engineering Research
2014;(8):1161-1164
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:With the development of tissue engineering, porous bioceramics are more and more used to repair bone defects. Current research focuses on the biological synthesis of this bioceramics and its performance evaluation.
OBJECTIVE:To discuss the preparation of a new kind of bone cement and to determine its physicochemical properties and biocompatibility with osteoblasts.
METHODS:Biphasic tricalcium phosphate powders were prepared using co-precipitation method. The powder was turned into granular stuff by arabic gum. After sintering, porous hydroxyapatite/tricalcium phosphate bioceramics were harvested, and then mixed with alpha-hemihydrate to prepare the bone cement.
RESULTS AND CONCLUSION:X-ray diffraction confirmed that the synthetic substance was a kind of biphasic calcium phosphate ceramic having a porous structure. The bone cement could be in the plastic state within 3 minutes. The curing time was 15 minutes, and the curing temperature was 36.5℃. The maximum compression strength was 5.82 MPa, and the MTT toxicity was level 0. Osteoblasts could grew wel on the material surface.
