Association between polymorphism of dopamine-β-hydroxylase genes and violent behavior in adolescents
10.3969/j.issn.1671-8348.2014.04.007
- VernacularTitle:青少年暴力行为与多巴胺β羟化酶基因多态性的关联分析
- Author:
Zhili ZOU
;
Huaqing MENG
;
Hua HU
;
Bo ZHOU
;
Zhongrui MA
;
Hongyin ZHANG
- Publication Type:Journal Article
- Keywords:
adolescent;
violence;
dopamine-beta-hydroxylase
- From:
Chongqing Medicine
2014;(4):401-403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the rs1611115 and rs739398 polymorphism of dopamine-β-hydroxy-lase genes and violent behavior in adolescents .Methods Adolescent male offenders were divided into violent group (107 samples) and nonviolent group (107 samples) .Besides ,107 male adolescents in vocational school were served as normal controls .The rs1611115 and rs739398 polymorphisms of DβH gene were measured by used SNaPshot SNP technology in 321 samples .Chi-square test was used to compare the distribution difference between three groups of each gene type and the allele frequency distribution . Results There was statistically significant difference among violent group ,nonviolent group and normal control group in the geno-type and allele frequencies of DβH gene rs1611115 polymorphism(P<0 .05) ,but there was no statistically significant difference be-tween violent group and nonviolent group(P>0 .05) .There was no statistically significant difference among violent group ,nonvio-lent group and normal control group in the genotype and allele frequencies of rs739398 polymorphism(P>0 .05) .Conclusion No association was found between the rs739398 polymorphism of DβH gene and adolescents with violent behavior .But the rs1611115 polymorphism of DβH gene was related to adolescent criminals with violent and nonviolent behavior .
