Expression of CXC chemokine 10 in chronic non-atrophy gastritis,carcinoma of stomach precancerous lesions and gastric cancer and their clinical significance
10.3969/j.issn.1671-8348.2014.04.002
- VernacularTitle:趋化因子10在慢性非萎缩性胃炎、胃癌癌前病变及胃癌中的表达及意义
- Author:
Tian HE
;
Hui TANG
;
Qiang GUO
;
Hui YANG
- Publication Type:Journal Article
- Keywords:
chemokine CXCL10;
stomach neoplasms;
chronic non-atrophic gastritis;
precancerous lesions
- From:
Chongqing Medicine
2014;(4):388-390
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of CXC chemokine 10(CXCL10) in chronic non-atrophy gastritis(CNAG) , precancerous lesions(PL)and gastric cancer(GC) ,primitively understanding of CXCL10 expression levels in three gastric types ,ex-ploring their clinical significances .Methods The expressions of CXCL10 in 20 cases of CNAG ,60 cases of PL ,60 cases of GC tis-sues were examined with immunohistochemistry method ,the expression level of CXCL10 was analyzed by computer-assisted image analysis system ,and then analyzed statistically .Results CXCL10 expression were positive in parts of CNAG ,PL and GC the posi-tive rates were 10 .00% ,26 .67% ,71 .67% respectively) .Expression levels of CXCL10 in the GC tissue specimens were significant-ly higher than in CNAG and PL(P<0 .01) .Expression levels of CXCL10 in the PL and CNAG tissue specimens have no significant difference(P>0 .05) .Expression levels of CXCL10 in CAG with IM ,CAG with Dys had no significant difference(P>0 .05) ,and in CAG with Severe Dys and Light-Moderate Dys had no significant difference(P>0 .05) .The expression levels of CXCL10 were rele-vant to the differentiation degree of GC (P>0 .05) .Conclusion The expression levels of CXCL10 were gradually rose from CNAG , PL to GC ,and had significant correlation with each other in CNAG ,PL and GC ,indicating that CXCL10 have a key role in the pro-duce and development of GC .
