The expression of PTTG,VEGF-C and LMVD in laryngeal carcinoma and the relationship among them
10.3969/j.issn.1671-8348.2014.04.022
- VernacularTitle:PT TG和 VEGF-C在喉癌组织中的表达及其与微淋巴管生成的关系
- Author:
Shan GAO
;
Guoyou LU
;
Zhujun WANG
;
Qin XU
;
Guohua XIN
;
Jina LIU
;
Yueyan HUANG
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor C;
laryngeal neoplasm;
density of microvessels;
PTTG
- From:
Chongqing Medicine
2014;(4):434-436
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of PTTG and VEGF-C in laryngeal carcinoma and the effect of angiogene-sis .Methods Immunohistochemistry was used to detect the expression of PTTG 、VEGF-C and LMVD in 60 cases of laryngeal car-cinoma and 32 cases of para-carcinoma tissue .D2 40 positive products was used to locate lymphatic endothelial cell cytoplasm and cell membrane ,and count lymphatic microvessel density (LMVD) .Results The expression of PTTG and VEGF-C in laryngeal car-cinoma was significantly higher than that in para-carcinoma tissue(P<0 .05) .In laryngeal carcinoma ,the expression of PTTG and VEGF-C were associated with differentiation ,lymph node metastasis and clinical stage(P<0 .05) ,but independent of clinical classi-fication ,smoking history ,tumor′size ,sex and gender(P>0 .05) .The expression of LMVD in laryngeal carcinoma was significantly higher than that in para-carcinoma tissue(P<0 .05) .The expression of LMVD was associated with lymph node metastasis (P<0 .05) ,but independent of differentiation ,clinical classification ,clinical stage smoking history ,tumor′size ,sex and gender ( P>0 .05) .A significantly positive relation was found between PTTG and VEGF-C(P<0 .05) .And there were positive relation between PTTG and LMVD、VEGF-C and LMVD(P<0 .05) .Conclusion PTTG and VEGF-C might play an important role in the carcino-genesis and development of laryngeal carcinoma .PTTG and VEGF-C could be a prognostic factor of colorectal cancer and a new tar-get of gene therapy .
