Method and Analysis of Click Induced Auditory BrainstemResponses of Normal Adult Mice
10.3969/j.issn.1006-7299.2014.02.009
- VernacularTitle:正常成年C57小鼠短声诱发听性脑干反应测试方法与波形分析
- Author:
Dengke LI
;
Lidong ZHAO
;
Weiwei GUO
;
Ning YU
;
Wei SUN
;
Shiming YANG
- Publication Type:Journal Article
- Keywords:
Mouse;
Auditory brainstem response;
Latency;
Threshold;
Amplitude
- From:
Journal of Audiology and Speech Pathology
2014;(2):145-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To obtain the auditory brainstem response (ABR)wave of normal adult mice ,and to analyze the thresholds ,latency and amplitudes to provide reference for future mice auditory research .Methods To determine the thresholds according to the high occurrence rate wave of click ABR at high (90 dB SPL) ,moderate (40 dB SPL)and low(20 dB SPL)sound intensities .thresholds ,latencies and amplitudes decreased as the wave with high occurrence rate .Results The occurrence rates of wave I ,II ,III ,IV ,and V were 100% ,100% ,100% ,75% 65% at high levels ;75% ,100% ,100% ,45% ,40% at moderate levels ,and 30% ,90% ,40% ,5% ,0% at low levels ,respec-tively .The results showed wave morphology was suitable to judging thresholds :the average threshold was 20 ± 5 .62 dB SPL ,latency and amplitude ranged from 2 .71 ± 0 .17~3 .08 ± 021 ms and 6 .20 ± 2 .24~1 .63 ± 0 .85 μV ,respectively , when sound intensities changed from 90 to 20 dB SPL .Conclusion Wave II is regarded as the best wave to determine threshold latency and amplitude .It will help future researches about mice auditory under pathophysiology conditions .
