Caveolin-1 and cerebrovascular disease
10.3760/cma.j.issn.1673-4165.2014.01.012
- VernacularTitle:陷窝蛋白-1与脑血管病
- Author:
Honghong LI
;
Ying PENG
- Publication Type:Journal Article
- Keywords:
Caveolin 1;
Brain Infarction;
Brain Ischemia;
Cerebral Hemorrhage;
Blood-Brain Barrier
- From:
International Journal of Cerebrovascular Diseases
2014;22(1):75-78
- CountryChina
- Language:Chinese
-
Abstract:
Caveolae are cholesterol-rich pits on the surface of cell membrane,and participate in various physiological processes.Caveolin-1 is an important membrane protein constituting caveolae.It exerts biological effects through binding a variety of signaling proteins.In the pathophysiological processes of cerebrovascular disease,caveolin-1 participates in maintaining the integrity of blood-brain barrier and stability of atherosclerotic plaques,and has regulating the release of inflammatory mediators and neuroprotection.This article reviews the associated advances in research on the correlation between caveolin-1 and cerebrovascular disease in order to provide a new idea for clinical therapy.
