Protective roles of lipoxin A4 in cerebral ischemia-reperfusion
10.3760/cma.j.issn.1673-4165.2014.01.010
- VernacularTitle:脂氧素A4在脑缺血再灌注中的保护作用
- Author:
Chengling LIU
;
Jiangquan HAN
;
Yongtao HU
- Publication Type:Journal Article
- Keywords:
Lipoxin A4;
Brain Ischemia;
Reperfusion Injury;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2014;22(1):67-71
- CountryChina
- Language:Chinese
-
Abstract:
Lipoxin A4 is an arachidonic acid metabolite,it is an important endogenous anti-inflammatory mediators in the body,which is known as an inflammatory braking signal. Inflammatory response is an important factor for causing cerebral ischemia-reperfusion injury.Lipoxin A4 can exert neuroprotective effects by inhibiting inflammatory response.In addition,lipoxin A4 can also reduce blood-brain barrier permeability,reduce cerebral edema,and promote recovery of neurological function.This article reviews the neuroprotective roles and mechanisms of lipoxin A4 in cerebral ischemia-reperfusion.
