Roles and their mechanisms of neuroglobin in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2014.01.009
- VernacularTitle:神经珠蛋白在脑缺血中的作用及其机制
- Author:
Liu LIU
;
Danfang LI
;
En XU
- Publication Type:Journal Article
- Keywords:
Nerve Tissue Proteins;
Globins;
Neuroglobin;
Brain Ischemia;
Signal Transduction;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2014;22(1):62-66
- CountryChina
- Language:Chinese
-
Abstract:
Neuroglobin (Ngb) is an oxygen-carrying globin that specifically expresses in brain tissue.It is involved in energy metabolism,mitochondrial function,as well as cell survival and proliferation of signaling pathway regulation.Under physiological conditions,Ngb presents as a form of ferrous deoxy hexacoordination,which has stronger oxygen affinity.During ischemia and hypoxia,the expression of Ngb is upregulated in brain tissue and interacts through a variety of proteins of its downstream,and plays a protective role for the damaged brain tissue.
