Glutamate transporter-1 and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2013.12.013
- VernacularTitle:谷氨酸转运体-1与脑缺血
- Author:
Huarong ZHOU
;
En XU
- Publication Type:Journal Article
- Keywords:
Excitatory Amino Acid Transporter 2;
Glutamic Acid;
Brain Ischemia
- From:
International Journal of Cerebrovascular Diseases
2013;21(12):942-946
- CountryChina
- Language:Chinese
-
Abstract:
Glutamate is an essential excitatory neurotransmitter which regulates brain functions.An increase in extracellular glutamate could excessively activate ionotropic glutamate receptors,initiate calcium overload,and lead to cell death after cerebral ischemia.Glutamate transporter-1 (GLT-1) is one of the major glutamate transporters expressed predominantly in astrocytes.Astrocytes also express the enzyme glutamine synthetase (GS) which converts the glutamate to glutamine; the latter is then 'recycled' into neurons.Pretreatment with ceftriaxone (CEF),ischemia and intermittent hypobaric hypoxia could lead to neuroprotection by increasing the expression of GLT-1 and regulating the activity of glutamate transporter in brain.
