MicroRNAs and ischemic stroke
10.3760/cma.j.issn.1673-4165.2013.12.012
- VernacularTitle:微小RNA与缺血性卒中
- Author:
Guomei ZHAO
;
Xudong PAN
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Stroke;
Brain Ischemia;
Atherosclerosis;
Neuroprotective Agents;
Biological Markers
- From:
International Journal of Cerebrovascular Diseases
2013;21(12):938-941
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are endogenous,small,non-coding,single-stranded RNA molecules,which can specifically bind to the 3'-terminal non-coding regions of mRNA chain to induce posttranscriptional gene silencing effect and regulate the expression of mRNA.Recent studies have shown that miRNAs have extensively involved in various pathophysiological processes,including atherosclerosis,cerebral ischemia and hypoxia tolerance,cerebral edema,neuronal cell death,suggesting miRNAs may be used as biological markers of the early diagnosis of ischemic stroke and the biological target of early treatment.This article reviews the biological characteristics of miRNAs,its relationship with ischemic stroke and mechanism of action in order to provide new evidence and ideas for miRNAs in the diagnosis and treatment of ischemic stroke.
