Regulatory T lymphocytes and ischemic stroke
10.3760/cma.j.issn.1673-4165.2013.12.011
- VernacularTitle:调节性T淋巴细胞与缺血性卒中
- Author:
Xiang CHEN
;
Dan YE
;
Yun XUN
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
T-Lymphocytes,Regulatory;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2013;21(12):933-937
- CountryChina
- Language:Chinese
-
Abstract:
Stroke is a cerebrovascular disease type with high morbidity and mortality,of which ischemic stroke accounts for about 80％.Now,it is believed that the inflammatory mechanisms play an important role in the progress of pathological physiology of ischemic stroke.Peripheral T lymphocytes infiltrate to the damaged area within 24 hours after cerebral ischemia and are involved in the advance of inflammatory process of brain tissue.As a subtype of T lymphocytes,regulatory T cells are mainly located in the ischemic penumbra; however,at present,its role in ischemic brain injury remains controversial.The research on the mechanisms of regulatory T cells in ischemic stroke may contribute to further understanding of the pathogenesis of ischemic stroke and find new therapeutic targets.
