Excretion and clinical value of fecal calprotectin in preterm infants during the first two weeks of life
10.3760/cma.j.issn.1673-4408.2014.02.025
- VernacularTitle:早产儿生后2周内粪便钙卫蛋白水平检测的临床研究
- Author:
Lian WANG
;
Juan LI
- Publication Type:Journal Article
- Keywords:
Calcium-binding proteins;
Feces;
Infant,Premature;
Enteral nutrition;
Feeding intolerance
- From:
International Journal of Pediatrics
2014;41(2):198-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the time course of fecal calprotectin (FC) excretion in preterm infants in the first two weeks of life and to identify influencing factors of FC levels.To explore whether FC may be an useful marker for the identification of gastrointestinal conditions in preterm infants.Methods FC concentration was measured using ELISA in 141 samples (50-100 mg)obtained from 47 preterm infants(gestational age less than 32 weeks or birth weight less than 1 200 grams)at birth,on day 7 and on day 14(The following was called FC1,FC2 and FC3 level for short).Results FC3 level was significantly higher than FC1 and FC2 levels (P ＜0.05),there were no significant differences between FC1 and FC2 levels in the 47 preterm infants(P ＞ 0.05).The FC1 level in infants whose mothers had antenatal infection was significantly higher(P ＜ 0.05).The FC2 level was negatively correlated with the antibiotic courses(r =-0.325,P ＜ 0.05).The FC2 level in infants with feeding intolerance was significantly lower than that in infants with feeding tolerance(P ＜ 0.05).The FC2 level in infants with feeding tolerance and the FC3 level in infants with feeding intolerance were positively correlated with the volume of enteral feeds,respectively (r =0.433,0.479,P ＜ 0.05).Contusion Antenatal infection and postnatal enteral feeds may lead to an increase in the excretion of FC in preterm infants.FC level was associated with enteral feeding and may be a useful marker for evaluation of gastrointestinal function in preterm infants.
