Progress of immunologic mechanisms of atopy on children's rheumatic diseases
10.3760/cma.j.issn.1673-4408.2014.01.019
- VernacularTitle:特应质对儿童风湿病发病的免疫机制研究进展
- Author:
Ruru GUO
- Publication Type:Journal Article
- Keywords:
Atopy;
Children;
Rheumatic diseases;
Immunological mechanism
- From:
International Journal of Pediatrics
2014;41(1):61-64
- CountryChina
- Language:Chinese
-
Abstract:
Children's rheumatic diseases,characterized with long disease course,systemic involvement,high morbidity and mortality rate and poor prognosis,deserve further attention in long-term treatment and follow-up.For now,there are many factors involved in the pathogenesis of rheumatic diseases,particularly the role of atopy atracted controversy.According to the conventional theory,Th1-type autoimmune diseases and Th2-mediated allergic diseases may have mutual antagonism in the pathogenesis,or that both kinds of diseases can co-exist and may contribute to a reduced disease severity.However,recent studies show that atopy may exert an adverse influence on children's rheumatic diseases,including higher severity,relapse-susceptibility,protracted remission and poorer outcomes.Recent researches have found that the underlying mechanisms of atopy on the development of rheumatic diseases can not be explained by the conventional Thl/Th2 theory.A complicated regulatory network of immune system,including Th17,Treg,NK,macrophagocyte,etc,may play a significant role in the development of the two kinds of diseases.This article provides up-to-date review on the immunological influence of atopy on children's rheumatic diseases at home and abroad.
