The progress on genes associated with early puberty
10.3760/cma.j.issn.1673-4408.2014.01.015
- VernacularTitle:青春发育提前的相关基因研究进展
- Author:
Chunyan CAI
- Publication Type:Journal Article
- Keywords:
Early puberty;
KISS1;
GPR54;
LIN28B;
MKRN3
- From:
International Journal of Pediatrics
2014;41(1):48-50
- CountryChina
- Language:Chinese
-
Abstract:
Puberty onset is triggered by re-emergence of the hypothalamic-pituitary-gonadal axis (HPGA),which is characterized by the significantly increasing amplitude and frequency of gonadotropin-releasing hormone (GnRH) secretion in human being.A series of studies found that many genes control puberty onset,including KISS1 and GPR54 gene,estrogen receptor (ESR) gene,energy balance-related genes,LIN28B gene,MKRN3 gene and so on.Studies have been confirmed that the mutation and single nucleotide polymorphisms (SNP) of the genes above are associated with early puberty.In this paper,the relationship between genetic alterations of these genes and early puberty are summarized as follows.-
