Advancement of Toll-like receptors in white matter damage
10.3760/cma.j.issn.1673-4408.2014.01.014
- VernacularTitle:Toll样受体在脑白质损伤中的研究进展
- Author:
Qingping WANG
- Publication Type:Journal Article
- Keywords:
Toll-like receptor;
White matter damage;
Signaling pathway;
Premature infant
- From:
International Journal of Pediatrics
2014;41(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
White matter damage in premature infant is the main form of brain damage in low birth and very low birth weight children,but its etiology and pathogenesis is not fully clear.Present studies show that Tolllike receptors(TLR) play an important role in the white matter damage mechanism.TLRs are regulators of innate immune responses.The studies have found that TLRs signaling pathway is activated to secrete large amounts of TNF-α,IL-1β,reactive oxygen species (ROS) and reactive nitrogen (RNS),NO,and other inflammatory factors,inducing the immune response.Nerve immune response damages brain white matter,namely the activation of microglia and proliferation of astrocytes in brain.TLRs provide a new research direction for prevention and treatment.Therefore,the research and progress of toll-like receptors in premature brain white matter injury disease are
