Progresses of tachykinins and its receptors in asthma
10.3760/cma.j.issn.1673-4408.2014.01.008
- VernacularTitle:速激肽及其受体在哮喘中的研究进展
- Author:
Liyun LIU
- Publication Type:Journal Article
- Keywords:
Tachykinin;
Substance P;
Neurokinin A;
Asthma
- From:
International Journal of Pediatrics
2014;41(1):25-28
- CountryChina
- Language:Chinese
-
Abstract:
Tachykinins are potent mediators of many functions in the airways.The tachykinins substance P and neurokinin A,presenting in human airways,can be recovered from the airways after a series of stimuli.They interact in the airways with tachykinin Neurokinin1,Neurokinin2 and Neurokinin3 receptors to cause bronchoconstriction,plasma extravasation,mucus secretion and to attract and activate immune cells and inflammation cells.They play a important role in the pathophysiology of asthma.However,the application of tachykinin receptor antagonists in clinic has been rather slow and somehow disappointing and needs to be further studied.
