Neuroprotective mechanism of erythropoietin on neonatal brain injury
10.3760/cma.j.issn.1673-4408.2014.01.006
- VernacularTitle:促红细胞生成素对新生儿脑保护的作用机制
- Author:
Lang LI
- Publication Type:Journal Article
- Keywords:
Erythropoietin;
Brain injury;
Neonate;
Nervous system
- From:
International Journal of Pediatrics
2014;41(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Brain injury is a significant cause leading to death of neonates with a considerable variety of complications.Up to now researches have found the neuroprotective actions of erythropoietin (EPO) originally identified as erythropoiesis on neonatal brain injury.EPO has been reported to induce a broad effect in the brain directed to protect and repair neurons damage which are likely to contribute to the improvement in long-term neurological functional outcomes.EPO may provide a new approach for promoting survival and growth in nerve cells and hold great promise for the future treatments of neonatal brain injury.EPO and EPO receptor distribute in defferent parts of brain in fetus and newborns.A fundamental mechanism of EPO-induced neuroprotection is its ability to inhibit apoptosis that EPO and EPO receptor have been shown to modulate three cellular signal transduction pathways.The other neuroprotection mechanisms of EPO-induced include anti-infammatory,neurotrophy,anti-oxidation,angiogenesis,promoting neurogenesis and anti-epilepsy.
